In this paper, we study computationally a mathematical model of post-traumatic stress disorder (PTSD). The PTSD is a common symptom resulted from a trauma or a long period of intense stress which leads to abnormal levels of hormonal secretion, especially in Cortisol. As a consequence, the neuronal electric activities also change due to variations in synaptic receptors regulated by hormone levels. We measure the hippocampal plasticity variability computationally through the synaptic spike-timing-dependent plasticity characterized in soma's calcium current in the neuronal system, and the results provide the evidence of long-term potentiation changes in a Hippocampus model due to PTSD.
CITATION STYLE
Xiao, P., Duan, L., & Su, J. (2016). The Synaptic Plasticity Variability in a Post-traumatic Stress Disorder Model (pp. 603–610). https://doi.org/10.1007/978-981-10-0207-6_81
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