MP78-09 THE ASSOCIATION BETWEEN GUT MICROBIOME AND ERECTILE DYSFUNCTION

Abstract

INTRODUCTION AND OBJECTIVE: Erectiledysfunction (ED) is associated with aging and lifestyle diseases. Dysbiosis (decreased diversity and change in gut microbiome) are observed inaging and several lifestyle diseases, such as, diabetic mellitus (DM), chronickidney disease (CKD), and cardiovascular disease (CVD). However, theassociation between the ED and dysbiosis remains unclear. We investigated gutmicrobiome in subjects with ED in a communitydwelling population. METHODS: This cross-sectional study analyzed 408 men who participated in the health promotion roject in Japan. We assessed participants' backgrounds and laboratory data. The gut microbiome composition was assessed by tag sequencing of the 16S rRNA gene extracted from fecal samples. Erectile function was assessed with the 5-item International Index of Erectile Function (IIEF-5) and the age adjusted participants were divided into two groups: the low-IIEF-5 (≤16) and high-IIEF-5 (>16). The diversity and dissimilarity of gut microbiome in each group were analyzed. The association of gut microbiome and a low-IIEF-5 was analyzed by multivariate logistic regression analysis. RESULTS: Of 408, age adjusted 192 men were selected. No significant differences in backgrounds were observed in the presence of hypertension, DM, CKD, and CVD between the low-IIEF-5 (n=96) and high-IIEF-5 (n = 96). There were no significant differences in the diversity and dissimilarity of gut microbiome between the two groups. However, the relative abundance of Odoribacter and Alistipes genera, which are thought to produce anti-inflammatory substances, were significantly lower in the low-IIEF-5 groups. Multivariate analysis showed that the relative abundance of Odoribacter + Alistipes genera (odds ratio = 0.81, P = 0.032) were independently associated with a low-IIEF-5. CONCLUSIONS: Odoribacter and Alistipes genera were significantly lower in subjects with low-IIEF-5. Further study is warranted to clarify a possible causal relationship between gut microbiome and ED. (Figure Presented).