The role of interleukin-10 in the inhibition of T-cell proliferation and apoptosis mediated by parainfluenza virus type 3

  • Sieg S
  • King C
  • Huang Y
  • et al.
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Abstract

We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhibition of T-cell proliferation and protects T cells from PIV3-mediated apoptosis. These findings suggest that IL-10 is likely to play an important immunoregulatory role in PIV3 infections.

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APA

Sieg, S., King, C., Huang, Y., & Kaplan, D. (1996). The role of interleukin-10 in the inhibition of T-cell proliferation and apoptosis mediated by parainfluenza virus type 3. Journal of Virology, 70(7), 4845–4848. https://doi.org/10.1128/jvi.70.7.4845-4848.1996

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