We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhibition of T-cell proliferation and protects T cells from PIV3-mediated apoptosis. These findings suggest that IL-10 is likely to play an important immunoregulatory role in PIV3 infections.
CITATION STYLE
Sieg, S., King, C., Huang, Y., & Kaplan, D. (1996). The role of interleukin-10 in the inhibition of T-cell proliferation and apoptosis mediated by parainfluenza virus type 3. Journal of Virology, 70(7), 4845–4848. https://doi.org/10.1128/jvi.70.7.4845-4848.1996
Mendeley helps you to discover research relevant for your work.