Antioxidants use in human cardiovascular disease - Where are we?

Abstract

Despite good basic science evidence for the benefit of antioxidants, clinical trials show little benefit from oral supplements containing one or several antioxidants. This chapter details the clinical trials and discusses possible reasons for the failure of oral antioxidant supplements. This analysis does not rule out a potential benefit from oral antioxidants in food, given the large benefits seen with the Mediterranean diet.