Computational study of betatrophin/ANGPTL8 and HBV interaction on lipoprotein lipase activity in the development of hepatocellular carcinoma caused by metabolic syndrome-related HBV infection

Abstract

Hepatocellular carcinoma is cancer, which is a significant problem in several countries in the world, one of which is Indonesia. The presence of hepatocellular carcinoma is often accompanied by the occurrence of the metabolic syndrome and infection of the HBV virus. Lipoprotein lipase (LPL) is an enzyme that is thought to be a key factor of metabolic syndrome occurrence and also HBV infection. This computational study aims to see the interaction between ANGPTL8 and HBV virus particles against LPL as a target. Our study shows that HBV and ANGPTL8 have different binding regions in the LPL enzyme so that they can bind simultaneously. Computationally HBV has stronger energy bonds than ANGPTL8. To sum up, this study can be the hallmark of another research to find out the role of LPL in the occurrence of Hepatocellular carcinoma by the binding of ANGPTL8 and HBV.