A number of polysaccharides with β-glycosidic linkage are widespread in nature in a variety of sources. All have a common structure and the (1→3)-β-D-glucan backbone is essential. They have attracted attention over the years because of their bioactive and medicinal properties. In many cases their functional role is a mystery, in others it is well established. Because of their insoluble chemical nature, particulate (1→3)-β-D- glucans are not suitable for many medical applications. Various methods of changing or modifying the β-D-glucan chemical structure and transforming it to a soluble form have been published. The β-D-glucan bioactive properties can be affected positively or negatively by such modifications. This review examines β-glucan sources in nature, health effects and structure-activity relationships. It presents the current state of β-D-glucan solubilization methods and discusses their effectiveness and application possibilities for the future. Copyright © Taylor & Francis Inc.
CITATION STYLE
Zeković, D. B., Kwiatkowski, S., Vrvić, M. M., Jakovljević, D., & Moran, C. A. (2005). Natural and modified (1→3)-β-D-glucans in health promotion and disease alleviation. Critical Reviews in Biotechnology. Informa Healthcare. https://doi.org/10.1080/07388550500376166
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