Viremia copy-years and mortality among combination antiretroviral therapy-initiating HIV-positive individuals: How much viral load history is enough?

Abstract

Objective: Ongoing HIV replication while receiving combination antiretroviral therapy (cART) may reduce survival. Viremia copy-years (VCY) has shown improved mortality risk prediction over single time-point viral load measures. However, the timing of a patient s viral load history most associated with later mortality has not been studied. Here we determined the optimal duration and temporality of viral load history for predicting mortality. Design: Survival analysis among HIV-positive men who initiated cART in the Multicenter AIDS Cohort Study (1995 2015). Methods: VCY measures were derived from area-under-The-viral load-curve. The overall VCY based upon the complete post-cART viral load history was compared with 20 VCYs derived from viral loads assessed during different shorter time periods (the most recent 1 10 years and initial 1 10 years following cART initiation) for associations with mortality. Results: Each 10-fold increase in VCYs based on the most recent 3 8 years was significantly associated with 23 26% decrease in survival times, a magnitude of effect greater than that of the most recent viral load (16%). These associations were independent of CD4 cell count and single time-point viral loads. In addition, the degree of precART immunodeficiency did not affect the mortality prognostic value of VCY based on viral loads in the most recent 3 years. Conversely, the overall VCY and VCYs based on viral loads immediately following cART initiation were not independent predictors of mortality. Conclusion: Among cART-Treated men, VCY based upon viral loads in the recent 3 years (six viral loads) has a mortality prognostic value greater than that of the overall VCY and single time-point viral loads, making the former a more feasible measure for use.