Epigenetic regulation of the hippocampus, with special reference to radiation exposure

8Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

The hippocampus is crucial in learning, memory and emotion processing, and is involved in the development of different neurological and neuropsychological disorders. Several epigenetic factors, including DNA methylation, histone modifications and non-coding RNAs, have been shown to regulate the development and function of the hippocampus, and the alteration of epigenetic regulation may play important roles in the development of neurocognitive and neurodegenerative diseases. This review summarizes the epigenetic modifications of various cell types and processes within the hippocampus and their resulting effects on cognition, memory and overall hippocampal function. In addition, the effects of exposure to radiation that may induce a myriad of epigenetic changes in the hippocampus are reviewed. By assessing and evaluating the current literature, we hope to prompt a more thorough understanding of the molecular mechanisms that underlie radiation-induced epigenetic changes, an area which can be further explored.

Cite

CITATION STYLE

APA

Saw, G., & Tang, F. R. (2020, December 2). Epigenetic regulation of the hippocampus, with special reference to radiation exposure. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms21249514

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free