Purpose of Review: To review the available literature regarding a possible relationship between vitamin D and bone marrow adipose tissue (BMAT), and to identify future avenues of research that warrant attention. Recent Findings: Results from in vivo animal and human studies all support the hypothesis that vitamin D can suppress BMAT expansion. This is achieved by antagonizing adipogenesis in bone marrow stromal cells, through inhibition of PPARγ2 activity and stimulation of pro-osteogenic Wnt signalling. However, our understanding of the functions of BMAT is still evolving, and studies on the role of vitamin D in modulating BMAT function are lacking. In addition, many diseases and chronic conditions are associated with low vitamin D status and low bone mineral density (BMD), but BMAT expansion has not been studied in these patient populations. Summary: Vitamin D suppresses BMAT expansion, but its role in modulating BMAT function is poorly understood.
CITATION STYLE
Sadie-Van Gijsen, H. (2019, December 1). The Regulation of Marrow Fat by Vitamin D: Molecular Mechanisms and Clinical Implications. Current Osteoporosis Reports. Springer. https://doi.org/10.1007/s11914-019-00546-6
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