Cerebral iron overload causes brain injury after intracerebral hemorrhage (ICH) in rats and pigs. The current study examined whether an iron chelator, deferoxamine, can reduce ICH-induced DNA damage in pigs. Pigs received an injection of autologous blood into the right frontal lobe. Deferoxamine (50 mg/kg, i.m.) or vehicle was given 2 h after ICH and then every 12 h up to 7 days. Animals were killed at day 3 or day 7 after ICH to examine iron accumulation and DNA damage. We found that ICH resulted in the development of a reddish perihematomal zone, with iron accumulation and DNA damage within that zone. Deferoxamine treatment reduced the perihematomal reddish zone, and the number of Perls' (p < 0.01) and TUNEL (p < 0.01) positive cells. In conclusion, iron accumulates in the perihematomal zone and causes DNA damage. Systemic deferoxamine treatment reduces ICH-induced iron overload and DNA damage in pigs. © 2011 Springer-Verlag/Wien.
CITATION STYLE
Gu, Y., Hua, Y., He, Y., Wang, L., Hu, H., Keep, R. F., & Xi, G. (2011). Iron accumulation and DNA damage in a pig model of intracerebral hemorrhage. In Acta Neurochirurgica, Supplementum (pp. 123–128). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-0693-8_20
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