Variant-beta luteinizing hormone is not associated with poor ovarian response to controlled ovarian hyperstimulation

0Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Background: The most common genetic variant of luteinizing hormone (LH), variant-betaLH, has a different bioactivity than the wildtype. Carrying the variant allele was associated with an increased consumption of exogenous gonadotropin to achieve optimal ovarian response for in vitro fertilization procedures (IVF). The aim of this study was to examine if variant-betaLH was also more common in patients with a poor ovarian response to exogenous gonadotropin which negatively influenced treatment outcome.Findings: 36 patients with poor ovarian response to ovarian stimulation for IVF and 98 controls with a normal response were genotyped for variant-betaLH using DNA sequencing. The carrier frequency in the control group was 17%. No association was found between poor ovarian response and variant-betaLH.Conclusions: Testing patients for variant-betaLH prior to IVF is unlikely to predict poor ovarian response. © 2014 Hanevik et al.; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Hanevik, H. I., Hilmarsen, H. T., Skjelbred, C. F., Tanbo, T., & Kahn, J. A. (2014). Variant-beta luteinizing hormone is not associated with poor ovarian response to controlled ovarian hyperstimulation. Reproductive Biology and Endocrinology, 12(1). https://doi.org/10.1186/1477-7827-12-20

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free