Producción de (+)-discodermólido por la esponja Discodermia dissoluta bajo sistemas de cultivo fijo y suspendido

Abstract

The and optimizemacrolide immunosuppressive and(+)-discodermolidelater obtain activity. the molecule However, producedof interest.by the the sustainable marineIn thisspongestudy, supply twoDiscodermia of any culture molecule systems—fixeddissoluta requires shows much andpromisingsuspended—were in situ and antitumor, in vitro evaluatedantimitotic, research to at 15-m depth in two sites, Punta de Betín and Nenguange, in Santa Marta (Colombian Caribbean). Survival, growth, and production of (+)-discodermolide were recorded, with the suspended system resulting in better growth and survival, depending on the culture site. The influence of the different environmental factors on survival was also studied, and a negative correlation with temperature was observed. Salinity, solar radiation, organic matter, and water flow were not correlated. Finally, no significant differences in the production of (+)-discodermolide existed between the culture systems and study sites. Production ranged from 20 to 270 μg per gram of dry sponge.