Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination

94Citations
Citations of this article
48Readers
Mendeley users who have this article in their library.

Abstract

Background: Therapy with tyrosine kinase inhibitors is associated with thyroid dysfunction. Decreased serum thyroid hormone levels during tyrosine kinase inhibitors are also observed in athyreotic patients with thyroid carcinoma. We therefore hypothesized that tyrosine kinase inhibitors may influence thyroid hormone metabolism. Aim: The aim was to study the effects of sorafenib therapy on serum thyroid hormone concentrations and iodothyronine deiodination in athyreotic patients. Design: The design included a prospective open, single-center, single-arm 26-wk study. Methods: We measured serum thyroxine (T4), free T4, 3,5,3-triiodothyronine (T 3), free T3, reverse T3 (rT3), and TSH concentrations at baseline and after 26 wk in 21 patients with progressive non-medullary thyroid carcinoma treated with sorafenib. Ratios of T 3/T4 and T3/rT3, which are independent of substrate availability and reflect iodothyronine deiodination, were calculated. Results: Serum free T4 and T3 levels, adjusted for levothyroxine dose per kilogram body weight, decreased by 11 and 18%, respectively, whereas TSH levels increased. The serum T3/T 4 and T3/rT3 ratios decreased by 18 and 22%, respectively, which is compatible with increased type 3 deiodination. Conclusions: Sorafenib enhances T4 and T3 metabolism, which is probably caused by increased type 3 deiodination. Copyright © 2010 by The Endocrine Society.

Cite

CITATION STYLE

APA

Abdulrahman, R. M., Verloop, H., Hoftijzer, H., Verburg, E., Hovens, G. C., Corssmit, E. P., … Smit, J. W. (2010). Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination. Journal of Clinical Endocrinology and Metabolism, 95(8), 3758–3762. https://doi.org/10.1210/jc.2009-2507

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free