Introduction: Primary filum terminale ependymoma (PFTE) is a unique type of ependymomas and locates on extramedullary site. However, the clinical features and prognostic factors of PFTE are still unknown due to its rarity. Aim: This study aimed to evaluate the clinical features, outcomes, and prognostic factors of PFTE in the largest series of cases. Result: Thirty-eight patients were included in this study. Gross total removal (GTR) of the tumors was achieved in 33(87%) patients. Five (13%) patients had subtotal resection (STR). For the residual tumors, postoperative radiotherapy increased the interval between the first surgery and tumor regrowth (P = 0.063). Six patients had local recurrence/progression. Univariate analysis identified STR(P = 0.001), unencapsulated tumor (P = 0.018), tumor involving more than two vertebral columns (P = 0.005), and tumor invading sacral canal(P < 0.001) as predictors of tumor recurrence. In addition, 36 (95%) patients had stable or improved neurological status directly after surgery. Klekamp-Samii score was better correlated with the symptoms than McCormick scale. Conclusion: Extent of surgical removal, tumor size, tumor location, and the integrity of tumor capsule are the prognostic factors of PFTEs, and the intrasacral PFTEs always have a poor prognosis. © 2013 John Wiley & Sons Ltd.
CITATION STYLE
Xie, T. H., Chen, X. Z., Qian, J., Lu, Y. C., Jiang, Y. K., Zhang, L., … Luo, C. (2014). Surgery for primary filum terminale ependymomas: Outcome and prognostic factors. CNS Neuroscience and Therapeutics, 20(2), 131–139. https://doi.org/10.1111/cns.12174
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