Protein-losing gastroenteropathy related to mixed connective tissue disease: A case report of a successful outcome and literature review

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Abstract

We herein report the case of a 44-year-old woman who developed protein-losing gastroenteropathy (PLGE) with hypoalbuminemia as the first manifestation of mixed connective tissue disease (MCTD). Albumin leakage from the stomach and intestinal tract was demonstrated by99mTc-labeled human serum albumin scintigraphy. The patient’s response to prednisolone therapy was insufficient; therefore, additional cyclosporin A (CsA) treatment was administered, and clinical remission was achieved. We concluded that although PLGE is a rare complication of MCTD, it may manifest as an initial clinical episode of MCTD. Furthermore, CsA can be a useful treatment option for refractory PLGE related to MCTD.

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Kobayashi, Y., Shimojima, Y., Kondo, Y., Takamatsu, R., Miyazaki, D., Kishida, D., … Ikeda, S. I. (2017). Protein-losing gastroenteropathy related to mixed connective tissue disease: A case report of a successful outcome and literature review. Internal Medicine. Japanese Society of Internal Medicine. https://doi.org/10.2169/internalmedicine.56.8391

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