A bacterial homologue of the human iron exporter ferroportin

5Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

A bacterial homologue of the human iron exporter ferroportin found in the predatory Gram-negative bacterium Bdellovibrio bacteriovorus has been investigated. Molecular modelling, expression in recombinant form and iron binding and transport assays demonstrate that B. bacteriovorus ferroportin (bdFpn) is indeed an orthologue of human ferroportin. Key residues corresponding to those essential for iron binding and transport in human ferroportin are conserved in the bacterial homologue and are predicted to be correctly clustered in the central cavity of the protein. Mutation of these residues grossly affects the iron binding and transport ability of bdFpn.

Cite

CITATION STYLE

APA

Bonaccorsi di Patti, M. C., Polticelli, F., Tortosa, V., Furbetta, P. A., & Musci, G. (2015). A bacterial homologue of the human iron exporter ferroportin. FEBS Letters, 589(24), 3829–3835. https://doi.org/10.1016/j.febslet.2015.11.025

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free