Avian influenza virus (H5N1) inactivation by binary ethylenimine

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Abstract

Avian influenza virus (AIV) subtype H5N1 is known as a highly pathogenic agent for man and various kinds of animals, especially avian species. Herein, AIV H5N1 was inactivated by binary ethylenimine (BEI), an aziridine compound, produced from 2-bromoethylamine hydrobromide. BEI was used at concentrations of 0.001 and 0.01 M for AIV inactivation. At the lower concentration (0.001 M), AIV could be inactivated within 24 hr. At the higher concentration (0.01 M), AIV could be inactivated within 6 hr. After inactivation, no hemagglutination activity had been found meaning that AIV had been completely inactivated.

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Sarachai, C., Sasipreeyajan, J., & Chansiripornchai, N. (2010). Avian influenza virus (H5N1) inactivation by binary ethylenimine. Thai Journal of Veterinary Medicine, 40(1), 41–46. https://doi.org/10.56808/2985-1130.2205

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