The endocannabinoid system in leptin-driven changes of orexinergic signaling under physiological and pathological conditions

Abstract

Abstract In this chapter, the neuroanatomical overlap in the distribution of orexin and endocannabinoid systems, as well as the functional interaction between leptindriven synaptic rewiring of orexinergic neurons and the orexin receptor-mediated activation of 2-arachidonoylglycerol synthesis, will be presented in the context of their role in the regulation of appetite, reward, sleep/wake, and analgesia. This chapter attempts to piece together what is known about this important cross talk and points out its potential therapeutic implications.