Assessment of serum bilirubin and hepatic enzymes in malaria patients

Abstract

Abstract Objectives:-The present study was conducted on malaria patients to observe the correlation between liver enzymes (SGOT, SGPT & ALP) and bilirubin. Material & Methods:-The study population contained 100 subjects divided into two groups, 60 malaria patients and 40 healthy control subjects of varying age groups and both sex. All biochemical parameters Total bilirubin, Direct bilirubin, Indirect bilirubin, SGOT (aspartate transaminase), SGPT (alanine transaminase) & ALP (alkaline phosphatise) were analyzed by semiautoanalyser. Statistical analysis was done by, science (SPSS 16) Software Results: - In our study we have found that (Mean ± SD) of Total serum bilirubin in malaria patients were 1.63±2.27 & controls were 0.67±0.08, Direct bilirubin in malarial patients were 0.92±1,3 & control were 0.37±0.07, Indirect bilirubin in malarial patients was 0.68±0.95. We observed that (Mean ±SD) of SGOT in malaria patients was 48.29±28.89 & in control were 29.28±7.44, the level of SGPT in malarial subjects were 44.9±27.15 & control subjects were 29.98±7.77 & the level of ALP in malarial patients were 98.47±60.67 & in control 71.4±25.12. We also found that both aminotransferases (SGOT & SGPT) showed significance positive correlation with serum total bilirubin levels whereas in case of ALP, significance correlation could not be obtained. Conclusion: Our study indicates that liver enzymes SGOP, SGPT and ALP significantly increases in malaria patients as compared to control subjects Therefore these enzymes may be useful in diagnosis of malaria subjects.