Differential requirement for utrophin in the induced pluripotent stem cell correction of muscle versus fat in muscular dystrophy mice

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Abstract

Duchenne muscular dystrophy (DMD) is an incurable degenerative muscle disorder. We injected WT mouse induced pluripotent stem cells (iPSCs) into mdx and mdx:utrophin mutant blastocysts, which are predisposed to develop DMD with an increasing degree of severity (mdx

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Beck, A. J., Vitale, J. M., Zhao, Q., Schneider, J. S., Chang, C., Altaf, A., … Fraidenraich, D. (2011). Differential requirement for utrophin in the induced pluripotent stem cell correction of muscle versus fat in muscular dystrophy mice. PLoS ONE, 6(5). https://doi.org/10.1371/journal.pone.0020065

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