Ginkgo biloba extract prevents acute myocardial infarction and suppresses the inflammation- and apoptosis-regulating p38 mitogen-activated protein kinases, nuclear factor-κB and B-cell lymphoma 2 signaling pathways

Abstract

Ginkgo biloba is a plant known from the Mesozoic and has been regarded as one of the first to be used in traditional Chinese medicine (TCM). The plant extract has attracted a great deal of attention in recent years. The Ginkgo biloba leaf contains flavones and diterpenes. In addition, Ginkgo biloba performs certain pharmacologic actions, including antioxidant and anti-aging activities. The aim of the present study was to examine whether Ginkgo biloba extract prevents acute myocardial infarction (AMI). The results demonstrated that Ginkgo biloba extract significantly inhibited infarct size, increased serum histamine levels and weakened creatine kinase (CK)-MB activity in AMI mice. Ginkgo biloba extract significantly inhibited serum interleukin (IL)-6 and IL-1β levels, and caspase-3/9 activity. In addition, it suppressed matrix metallopeptidase-9, transforming growth factor-β, p38 mitogen-activated protein kinases (MAPK) and nuclear factor (NF)-κB protein expression, and promoted B-cell lymphoma 2 (Bcl-2) protein expression in AMI mice. The results of in vivo assays demonstrated that Ginkgo biloba extract prevents AMI and suppresses inflammation- and apoptosis-regulating p38 MAPK, NF-κB and Bcl-2 signaling pathways.