The simulation of protein aggregation poses several computational challenges due to the disparate time and lengths scales that are involved. This chapter focuses on the use of atomistically detailed simulations to probe the initial steps of aggregation, with an emphasis on the Tau peptide as a model system, run under a replica exchange molecular dynamics protocol
CITATION STYLE
Shea, J. E., & Levine, Z. A. (2016). Studying the early stages of protein aggregation using replica exchange molecular dynamics simulations. In Methods in Molecular Biology (Vol. 1345, pp. 225–250). Humana Press Inc. https://doi.org/10.1007/978-1-4939-2978-8_15
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