Carence en vitamine B12 (1re partie): Mise au point

Abstract

Vitamin B12 deficiency is classically accompanied by a megaloblastic anemia, neuropsychiatric disorders and an Hunter glossitis. Clinical manifestations are indeed polymorphic and each may remain the only one for a long period of time. Stomatological manifestations, often mild, may precede the others of many years. They sometimes are the first sign to early diagnose this deficiency. Since the last ten years, the physiopathology of vitamin B12 deficiency has considerably changed. In fact, nowadays, the main cause is the syndrome of food cobalamin malabsorption. It has also been demonstrated that the deficiency may now treated by an oral cobalamin therapy. © SFMBCB 2011.