UV-Vis Spectrophotometrical and Analytical Methodology for the Determination of Singlet Oxygen in New Antibacterials Drugs

  • Zoltan T
  • Vargas F
  • Izzo C
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Abstract

We have determined and quantified spectrophotometrically the capacity of producing reactive oxygen species (ROS) as 1 O 2 during the photolysis with UV-A light of 5 new synthesized naphthyl ester derivates of well-known quinolone antibacterials (nalidixic acid (1), cinoxacin (2), norfloxacin (3), ciprofloxacin (4) and enoxacin (5)). The ability of the naphthyl ester derivatives (6-10) to generate singlet oxygen were detecting and for the first time quantified by the histidine assay, a sensitive, fast and inexpensive method. The following tendency of generation of singlet oxygen was observed: compounds 7 >10 > 6 > 8 > 9 >> parent drugs 1-5.

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Zoltan, T., Vargas, F., & Izzo, C. (2007). UV-Vis Spectrophotometrical and Analytical Methodology for the Determination of Singlet Oxygen in New Antibacterials Drugs. Analytical Chemistry Insights, 2, 117739010700200. https://doi.org/10.4137/117739010700200015

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