Background/Purpose: Pulmonary hypoplasia contributes to mortality in infants with severe congenital diaphragmatic hernia (CDH). Accelerated postnatal lung growth with perfluorocarbon lung distension has been demonstrated in animals. The authors present a study measuring perfluorodecalin distension in neonates with severe CDH on extracorporeal membrane oxygenation (ECMO) support. Methods: Six consecutive neonates with CDH requiring ECMO support were recruited. The lungs were filled with perfluorodecalin, and continuous positive airway pressure was applied for 6 to 10 days (mean, 7.7 days ± 0.7). The perfluorodecalin was exchanged 4 times a day. Radiographic lung projections were measured, and from 2-dimensional measurements an estimated lung volume was calculated using the ECMO cannula as reference. Results: Perfluorodecalin instillation started soon after starting ECMO support (mean, 13.5 ± 5.3 hours). The volume required to fill the lungs increased significantly (P
CITATION STYLE
Walker, G. M., Kasem, K. F., O’Toole, S. J., Watt, A., Skeoch, C. H., & Davis, C. F. (2003). Early perfluorodecalin lung distension in infants with congenital diaphragmatic hernia. Journal of Pediatric Surgery, 38(1), 17–20. https://doi.org/10.1053/jpsu.2003.50002
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