Early perfluorodecalin lung distension in infants with congenital diaphragmatic hernia

28Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Background/Purpose: Pulmonary hypoplasia contributes to mortality in infants with severe congenital diaphragmatic hernia (CDH). Accelerated postnatal lung growth with perfluorocarbon lung distension has been demonstrated in animals. The authors present a study measuring perfluorodecalin distension in neonates with severe CDH on extracorporeal membrane oxygenation (ECMO) support. Methods: Six consecutive neonates with CDH requiring ECMO support were recruited. The lungs were filled with perfluorodecalin, and continuous positive airway pressure was applied for 6 to 10 days (mean, 7.7 days ± 0.7). The perfluorodecalin was exchanged 4 times a day. Radiographic lung projections were measured, and from 2-dimensional measurements an estimated lung volume was calculated using the ECMO cannula as reference. Results: Perfluorodecalin instillation started soon after starting ECMO support (mean, 13.5 ± 5.3 hours). The volume required to fill the lungs increased significantly (P

Cite

CITATION STYLE

APA

Walker, G. M., Kasem, K. F., O’Toole, S. J., Watt, A., Skeoch, C. H., & Davis, C. F. (2003). Early perfluorodecalin lung distension in infants with congenital diaphragmatic hernia. Journal of Pediatric Surgery, 38(1), 17–20. https://doi.org/10.1053/jpsu.2003.50002

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free