Myrrh inhibits LPS-induced inflammatory response and protects from cecal ligation and puncture-induced sepsis

25Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Myrrh has been used as an antibacterial and anti-inflammatory agent. However, effect of myrrh on peritoneal macrophages and clinically relevant models of septic shock, such as cecal ligation and puncture (CLP), is not well understood. Here, we investigated the inhibitory effect and mechanism(s) of myrrh on inflammatory responses. Myrrh inhibited LPS-induced productions of inflammatory mediators such as nitric oxide, prostaglandin E2, and tumor necrosis factor- but not of interleukin (IL)-1Β and IL-6 in peritoneal macrophages. In addition, Myrrh inhibited LPS-induced activation of c-jun NH2-terminal kinase (JNK) but not of extracellular signal-regulated kinase (ERK), p38, and nuclear factor-B. Administration of Myrrh reduced the CLP-induced mortality and bacterial counts and inhibited inflammatory mediators. Furthermore, administration of Myrrh attenuated CLP-induced liver damages, which were mainly evidenced by decreased infiltration of leukocytes and aspartate aminotransferase/alanine aminotransferase level. Taken together, these results provide the evidence for the anti-inflammatory and antibacterial potential of Myrrh in sepsis.

References Powered by Scopus

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

7111Citations
N/AReaders
Get full text

The pathophysiology and treatment of sepsis

3416Citations
N/AReaders
Get full text

LPS induction of gene expression in human monocytes

2081Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Ferulic acid protects lipopolysaccharide-induced acute kidney injury by suppressing inflammatory events and upregulating antioxidant defenses in Balb/c mice

90Citations
N/AReaders
Get full text

Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: A randomized, double-blind, vehicle-controlled study

62Citations
N/AReaders
Get full text

Tyrosol attenuates lipopolysaccharide-induced acute lung injury by inhibiting the inflammatory response and maintaining the alveolar capillary barrier

44Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Park, S. J., Kim, M. S., Bae, G. S., Park, K. C., Koo, B. S., Kim, B. J., … Song, H. J. (2012). Myrrh inhibits LPS-induced inflammatory response and protects from cecal ligation and puncture-induced sepsis. Evidence-Based Complementary and Alternative Medicine, 2012. https://doi.org/10.1155/2012/278718

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 14

88%

Professor / Associate Prof. 1

6%

Researcher 1

6%

Readers' Discipline

Tooltip

Medicine and Dentistry 11

61%

Agricultural and Biological Sciences 4

22%

Immunology and Microbiology 2

11%

Chemical Engineering 1

6%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1
Social Media
Shares, Likes & Comments: 3

Save time finding and organizing research with Mendeley

Sign up for free