Assessment of cardiovascular system abnormalities in patients with advanced primary hyperparathyroidism by detailed echocardiographic analysis: A prospective study

Abstract

Aim: Recognizing the paucity of data regarding the incidence of cardiovascular abnormalities in severe primary hyperparathyroidism (PHPT), a prospective study was done for left ventricular (LV) systolic and diastolic function by echocardiography in patients with hyperparathyroidism (HPT) before surgery. Materials and methods: A total of 18 consecutive patients with HPT and an equal number of age- and sex-matched controls were studied by two-dimensional and Doppler echocardiography. Results: Patients with HPT had higher systolic and diastolic blood pressures (BPs). Despite severe bone disease, nephropathy, and vitamin D deficiency, none had metastatic calcification in myocardium. There was no significant increase in LV systolic dimensions and volume, but decreased ejection fraction (EF) and significant diastolic dysfunction were observed. Conclusion: Despite an asymptomatic cardiac status, there were decreased EF and significant diastolic dysfunction. The HPT patients despite having severe disease, did not have metastatic calcification.