New C-substituted (1S,4S)-2,5-diazabicyclo[2.2.1]heptane derivatives. Preparation utilizing the directed metalation strategy. Application in enantioselective catalysis

Abstract

New C-substituted derivatives of (1S,4S)-2-methyl-2,5-diazabicyclo[2.2.1] heptane were synthesized utilizing the directed metalation strategy. The absolute configuration of the 3-substituted derivative rests on the comparison of the NMR spectra with a product of proven configurational assignment by X-ray crystallographic analysis.