Precocious puberty or premature thelarche: Analysis of a large patient series in a single tertiary center with special emphasis on 6- to 8-year-old girls

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Abstract

Introduction: We describe the etiology, MRI fndings, and growth patterns in girls who had presented with signs of precocious puberty (PP), i.e., premature breast development or early menarche. Special attention was paid to the diagnostic fndings in 6- to 8-year-olds. Materials and methods: We reviewed the medical records of 149 girls (aged 0.7- 10.3 years) who had been evaluated for PP in the Helsinki University Hospital between 2001 and 2014. results: In 6- to 8-year-old girls, PP was most frequently caused by idiopathic gonadotropin- releasing hormone (GnRH)-dependent PP (60%) and premature thelarche (PT; 39%). The former subgroup grew faster (8.7 ± 2.0 cm/year, n = 58) than the girls with PT (7.0 ± 1.1 cm/year, n = 32) (P < 0.001), and the best discrimination for GnRH-dependent PP was achieved with a growth velocity cut-off value of 7.0 cm/year (sensitivity 92% and specifcity 58%) [area under the curve 0.82, 95% confdence interval (CI) 0.73-0.91, P < 0.001]. Among asymptomatic and previously healthy 6- to 8-year-old girls with GnRH-dependent PP, one (1.7%, 95% CI 0.3-9.7%) had a pathological brain MRI fnding requiring surgical intervention (craniopharyngioma). In girls younger than 3 years, the most frequent cause of breast development was PT, and, in 3- to 6-year-olds, GnRHdependent PP. conclusion: In 6- to 8-year-old girls, analysis of growth velocity is helpful in differentiating between PT and GnRH-dependent PP. Although the frequency of clinically relevant intracranial fndings in previously healthy, asymptomatic 6- to 8-year-old girls was low, they can present without any signs or symptoms, which favors routine MRI imaging also in this age group.

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Varimo, T., Huttunen, H., Miettinen, P. J., Kariola, L., Hietamäki, J., Tarkkanen, A., … Raivio, T. (2017). Precocious puberty or premature thelarche: Analysis of a large patient series in a single tertiary center with special emphasis on 6- to 8-year-old girls. Frontiers in Endocrinology, 8(AUG). https://doi.org/10.3389/fendo.2017.00213

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