A practical electrochemical method for the rapid, safer, and mild synthesis of tertiary hindered alkyl fluorides from carboxylic acids has been developed without the need for hydrofluoric acid salts or non-glass reactors. In this anodic fluorination, collidinium tetrafluoroborate acts as both the supporting electrolyte and fluoride donor. A wide range of functional groups has been shown to be compatible, and the possibility of scale-up using flow electrochemistry has also been demonstrated.
CITATION STYLE
Leech, M. C., Nagornîi, D., Walsh, J. M., Kiaku, C., Poole, D. L., Mason, J., … Lam, K. (2023). eFluorination Using Cheap and Readily Available Tetrafluoroborate Salts. Organic Letters, 25(9), 1353–1358. https://doi.org/10.1021/acs.orglett.2c04305
Mendeley helps you to discover research relevant for your work.