Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor β locus

Abstract

A gene for a second type of human estrogen receptor, the estrogen receptor β (ESRβ), was recently identified. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human estrogen receptor β gene. High heterozygosity(0.93) makes this polymorphism a useful marker in the genetic study of disorders affecting female endocrine systems; calcium metabolism; and breast, uterine, and ovarian cancers.