Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile?

14Citations
Citations of this article
41Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Inflammasomes are multiprotein complexes that form in the cytoplasm in response to cellular damage and cytosolic pathogen-associated molecules during infection. These complexes play important roles in initiating innate and adaptive immune responses to infectious disease. In addition, inflammasomes are now recognized as important mediators of sterile inflammation in various autoimmune and autoinflammatory diseases. Interestingly, microbiota and infection play critical roles in the development of ‘sterile inflammation’. Herein, we highlight recent advances in our understanding of the role for inflammasomes in nucleic acid-, nucleosome-, and histone-driven sterile inflammation and discuss knowledge gaps and areas of potential future research.

Cite

CITATION STYLE

APA

Lupfer, C. R., Rodriguez, A., & Kanneganti, T. D. (2017, August 1). Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile? FEBS Journal. Blackwell Publishing Ltd. https://doi.org/10.1111/febs.14076

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free