Abstract
Tropomyosin I (TMI) is downregulated in a number of transformed cell types, and exogenous expression of TMI can restore actin organisation and reverse cellular transformation. We find that TMI is also downregulated in human neuroblastoma cell lines, correlating with increasing malignancy. However, exogenous TMI does not restore actin cytoskeleton organisation in neuroblastoma cells. © 2003 Cancer Research UK.
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Yager, M. L., Hughes, J. A. I., Lovicu, F. J., Gunning, P. W., Weinberger, R. P., & O’Neill, G. M. (2003). Functional analysis of the actin-binding protein, tropomyosin I, in neuroblastoma. British Journal of Cancer, 89(5), 860–863. https://doi.org/10.1038/sj.bjc.6601201
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