Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates

  • Ibrahim M
  • Elsaman T
  • Al-Nour M
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Abstract

The design, synthesis, and development of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower side effects are respectable area of research. Novel Diclofenac Schiff’s bases ( M1, M2, M4, M7, and M8 ) were designed and synthesized, and their respective chemical structures were deduced using various spectral tools (IR, 1 H NMR, 13 C NMR, and MS). The compounds were synthesized via Schiff’s condensation reaction and their anti-inflammatory activity was investigated applying the Carrageenan-induced paw edema model against Diclofenac as positive control. Percentage inhibition of edema indicated that all compounds were exhibiting a comparable anti-inflammatory activity as Diclofenac. Moreover, the anti-inflammatory activity was supported via virtual screening using molecular docking study. Interestingly compound M2 showed the highest in vivo activity (61.32% inhibition) when compared to standard Diclofenac (51.36% inhibition) as well as the best binding energy score (-10.765) and the virtual screening docking score (-12.142).

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Ibrahim, M. M., Elsaman, T., & Al-Nour, M. Y. (2018). Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates. International Journal of Medicinal Chemistry, 2018, 1–11. https://doi.org/10.1155/2018/9139786

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