Clinical efficacy of aldosterone-blocking agents

Abstract

Aldosterone has an important role in end-organ damage in hypertension, post-MI-cardiac remodelling, and heart failure. Accordingly blockers of the aldosterone receptor such as spironolactone and eplerenone have gained widespread use in the treatment of (post-MI) heart failure. The article outlines the clinical evidence on the efficacy of aldosterone blocking agents in heart failure and hypertension and outlines clinical perspectives for their use. © 2011 The Author.