Legionnaires' disease at a Dutch flower show: Prognostic factors and impact of therapy

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Abstract

After a large outbreak of Legionnaires' disease in the Netherlands, we determined risk factors for intensive care unit (ICU) admission and death and the impact of adequate therapy on ICU-free survival among 141 hospitalized patients. Overall mortality rate was 13%, and ICU mortality rate was 36%. Smoking, temperature >38.5°C, and bilateral infiltrates shown on chest x-ray were independent risk factors for ICU admission or death (all p<0.05). Starting adequate therapy within 24 hours after admission resulted in a higher ICU-free survival rate compared to therapy initiation after 24 hours: 78% versus 54%, respectively (p=0.005). However, delay in providing therapy to patients with urinary antigen tests with negative results did not influence outcome. These data suggest that by using the urinary antigen test on admission a more tailored approach to patients with community-acquired pneumonia may be applied.

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Lettinga, K. D., Verbon, A., Weverling, G. J., Schellekens, J. F. P., Den Boer, J. W., Yzerman, E. P. F., … Speelman, P. (2002). Legionnaires’ disease at a Dutch flower show: Prognostic factors and impact of therapy. Emerging Infectious Diseases, 8(12), 1448–1454. https://doi.org/10.3201/eid0812.020035

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