Currently, colon cancer diagnosis is based on manual assessment of tissue samples stained with hematoxylin and eosin (H&E). This is a high volume, time consuming, and subjective task which could be aided by automatic cancer detection. We propose an algorithm for automatic cancer detection within WSI H&E stains using a multi class colon tissue classifier based on features extracted from 5 different color representations. Approx. 32000 tissue patches were extracted for the classifier from manual annotations of 9 representative colon tissue types from 74 WSI H&E stains. Colon tissue classifiers based on gray level or color features were trained using leave-one-out forward selection. The best colon tissue classifier was based on color texture features obtaining an average tissue precision-recall (PR) area under the curve (AUC) of 0.886 and a cancer PR-AUC of 0.950 on 20 validation WSI H&E stains.
CITATION STYLE
Jørgensen, A. S., Emborg, J., Røge, R., & Østergaard, L. R. (2018). Exploiting Multiple Color Representations to Improve Colon Cancer Detection in Whole Slide H&E Stains. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 11039 LNCS, pp. 61–68). Springer Verlag. https://doi.org/10.1007/978-3-030-00949-6_8
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