Clinical significance of pre-operative neutrophil lymphocyte ratio and platelet lymphocyte ratio as prognostic factors for patients with colorectal cancer

92Citations
Citations of this article
78Readers
Mendeley users who have this article in their library.

Abstract

The present study aimed to investigate the independent prognostic values of the pre-operative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). The present study retrospectively analyzed the data of 216 patients with CRC from a single hospital. The clinicopathological characteristics of the patients were compared and prognostic factors were evaluated. NLR and PLR were associated with tumor differentiation status and the tumor diameter, respectively, and PLR was also associated with the primary tumor classification (T classification). Furthermore, NLR and PLR were positively associated with each other (R2=0.5368; P<0.0001). Univariate analyses indicated that stage II and III patients with a high NLR (≥4.98; P<0.001) or PLR (≥246.36; P<0.001) possessed a significantly poorer 5-year OS rate compared with those with a low NLR or PLR. Post-operative adjuvant chemotherapy improved the 5-year OS rate in patients with a high NLR or PLR. Multivariate analyses indicated that NLR and PLR were independent prognostic factors [NLR, relative risk (RR)=4.074 and P<0.001; PLR, RR=2.029 and P=0.029] in patients with CRC, and were associated with the T classification, lymph node metastasis and post-operative adjuvant chemotherapy response of patients. Additionally, the area under the curve (AUC) was 0.748 for NLR (95% CI, 0.684-0.804; P<0.0001) and 0.690 for PLR (95% CI, 0.623-0.751; P<0.0001). The RR and AUC indicated that NLR was the superior predictive factor in patients with CRC. In conclusion, the pre-operative NLR and PLR were significant independent prognostic factors in patients with CRC, and NLR was more effective as a prognostic marker compared with PLR. Adjuvant chemotherapy appeared to be more effective in CRC patients with a higher NLR or PLR.

References Powered by Scopus

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

23781Citations
N/AReaders
Get full text

Inflammation and cancer

12678Citations
N/AReaders
Get full text

Immunity, Inflammation, and Cancer

8827Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Breast cancer—epidemiology, risk factors, classification, prognostic markers, and current treatment strategies—An updated review

877Citations
N/AReaders
Get full text

Systemic immune-inflammation index for predicting prognosis of colorectal cancer

465Citations
N/AReaders
Get full text

Inflammation-related biomarkers for the prediction of prognosis in colorectal cancer patients

246Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zou, Z. Y., Liu, H. L., Ning, N., Li, S. Y., Du, X. H., & Li, R. (2016). Clinical significance of pre-operative neutrophil lymphocyte ratio and platelet lymphocyte ratio as prognostic factors for patients with colorectal cancer. Oncology Letters, 11(3), 2241–2248. https://doi.org/10.3892/ol.2016.4216

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 19

50%

Researcher 15

39%

Professor / Associate Prof. 3

8%

Lecturer / Post doc 1

3%

Readers' Discipline

Tooltip

Medicine and Dentistry 37

80%

Biochemistry, Genetics and Molecular Bi... 4

9%

Immunology and Microbiology 3

7%

Psychology 2

4%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free