Integrating Cdk signaling in Candida albicans environmental sensing networks

Abstract

Cyclin-dependent protein kinases (Cdks) control cell cycle progression and morphological switches in eukaryotic cells. Based on recent findings concerning the evolution of Cdk phosphorylation sites in the Ascomycete linage, we shall analyze the density of Cdk motifs in the Candida proteome using the S LR algorithm, focusing on protein sequences of regulatory modules that play important roles in the environmental sensing of Candida albicans. Since Cdks are also involved in morphogenesis and environmental signaling, this search could help us to speculate about how Cdk signaling might be integrated in these regulatory networks that control C. albicans morphopathogenic determinants. © 2012 Springer-Verlag Berlin Heidelberg.