Genome-wide association study (GWAS) is a powerful study design to identify genetic variants of a trait and, in particular, detect the association between common single-nucleotide polymorphisms (SNPs) and common human diseases such as heart disease, inflammatory bowel disease, type 2 diabetes, and psychiatric disorders. The standard strategy of population-based case-control studies for GWAS is illustrated in this chapter. We provide an overview of the concepts underlying GWAS, as well as provide guidelines for statistical methods performed in GWAS.
CITATION STYLE
Chang, M., He, L., & Cai, L. (2018). An overview of genome-wide association studies. In Methods in Molecular Biology (Vol. 1754, pp. 97–108). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7717-8_6
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