Application of a 2D Molybdenum Telluride in SERS Detection of Biorelevant Molecules

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Abstract

Two-dimensional (2D) transition-metal dichalcogenides have become promising candidates for surface-enhanced Raman spectroscopy (SERS), but currently very few examples of detection of relevant molecules are available. Herein, we show the detection of the lipophilic disease marker β-sitosterol on few-layered MoTe2 films. The chemical vapor deposition (CVD)-grown films are capable of nanomolar detection, exceeding the performance of alternative noble-metal surfaces. We confirm that the enhancement occurs through the chemical enhancement (CE) mechanism via formation of a surface-analyte complex, which leads to an enhancement factor of ≈104, as confirmed by Fourier transform infrared (FTIR), UV-vis, and cyclic voltammetry (CV) analyses and density functional theory (DFT) calculations. Low values of signal deviation over a seven-layered MoTe2 film confirms the homogeneity and reproducibility of the results in comparison to noble-metal substrate analogues. Furthermore, β-sitosterol detection within cell culture media, a minimal loss of signal over 50 days, and the opportunity for sensor regeneration suggest that MoTe2 can become a promising new SERS platform for biosensing.

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Fraser, J. P., Postnikov, P., Miliutina, E., Kolska, Z., Valiev, R., Švorčík, V., … Guselnikova, O. (2020). Application of a 2D Molybdenum Telluride in SERS Detection of Biorelevant Molecules. ACS Applied Materials and Interfaces, 12(42), 47774–47783. https://doi.org/10.1021/acsami.0c11231

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