Unraveling Resistance Mechanisms against New Antimicrobials Using Transposon Mutagenesis

Abstract

Transposon mutagenesis historically has been an invaluable tool for the discovery of bacterial gene functions and for the identification of numerous cell processes, including those related to bacterial virulence and pathogenesis. This review discusses the role of transposition in the emergent research field of identifying genes involved in the mechanisms of resistance to antivirulence compounds, biofilm inhibitors, and non-redox iron analogs.