A Cu2(OBA)2(BPY) metal-organic framework was utilized as a productive heterogeneous catalyst for the synthesis of 3-aroylquinolines via one-pot domino reactions of 2-aminobenzylalcohols with propiophenones. This Cu-MOF was considerably more active towards the one-pot domino reaction than a series of transition metal salts, as well as nano oxide and MOF-based catalysts. The MOF-based catalyst was reusable without a significant decline in catalytic efficiency. To the best of our knowledge, the transformation of 2-aminobenzylalcohols to 3-aroylquinolines was not previously reported in the literature, and this protocol would be complementary to previous strategies for the synthesis of these valuable heterocycles.
CITATION STYLE
Dang, H. V., Le, H. T. B., Tran, L. T. B., Ha, H. Q., Le, H. V., & Phan, N. T. S. (2018). Copper-catalyzed one-pot domino reactions via C-H bond activation: Synthesis of 3-aroylquinolines from 2-aminobenzylalcohols and propiophenones under metal-organic framework catalysis. RSC Advances, 8(55), 31455–31464. https://doi.org/10.1039/c8ra05459b
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