Copper-catalyzed one-pot domino reactions via C-H bond activation: Synthesis of 3-aroylquinolines from 2-aminobenzylalcohols and propiophenones under metal-organic framework catalysis

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Abstract

A Cu2(OBA)2(BPY) metal-organic framework was utilized as a productive heterogeneous catalyst for the synthesis of 3-aroylquinolines via one-pot domino reactions of 2-aminobenzylalcohols with propiophenones. This Cu-MOF was considerably more active towards the one-pot domino reaction than a series of transition metal salts, as well as nano oxide and MOF-based catalysts. The MOF-based catalyst was reusable without a significant decline in catalytic efficiency. To the best of our knowledge, the transformation of 2-aminobenzylalcohols to 3-aroylquinolines was not previously reported in the literature, and this protocol would be complementary to previous strategies for the synthesis of these valuable heterocycles.

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Dang, H. V., Le, H. T. B., Tran, L. T. B., Ha, H. Q., Le, H. V., & Phan, N. T. S. (2018). Copper-catalyzed one-pot domino reactions via C-H bond activation: Synthesis of 3-aroylquinolines from 2-aminobenzylalcohols and propiophenones under metal-organic framework catalysis. RSC Advances, 8(55), 31455–31464. https://doi.org/10.1039/c8ra05459b

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