Two-photon uncageable enzyme inhibitors bearing targeting vectors

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Abstract

The activity of two cyclooxygenase-2 enzyme inhibitors, Celecoxib and Lumiracoxib, could be suppressed by coupling to photo-labile protecting groups, so-called photocages. These groups could be further functionalized with a peptide targeting vector for specific cellular delivery. The enzyme inhibition potential of the cyclooxygenase-2 inhibitors could be regained upon two-photon excitation with tissue-transparent near-IR light at 800 nm.

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Anstaett, P., Pierroz, V., Ferrari, S., & Gasser, G. (2015). Two-photon uncageable enzyme inhibitors bearing targeting vectors. Photochemical and Photobiological Sciences, 14(10), 1821–1825. https://doi.org/10.1039/c5pp00245a

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