Aging skeletal muscle: Physiologic changes and the effects of training

Abstract

Changes occur in skeletal muscle with aging. The most apparent changes are decreases in muscle CSA and the volume of contractile tissue within that CSA. Changes also occur in the function of muscle fibers, in MU firing characteristics, and in the aerobic capacity of skeletal muscle. The results of these changes are decreased force production and often decreased function. There is evidence that exercise can have an impact on the size, strength, and aerobic capacity of skeletal muscle in older people. Research suggests that regular exercise including strength and endurance training of adequate intensity can reduce some of the physiologic effects of aging seen in skeletal muscle.