HIV mono-infection is associated with FIB-4 - A noninvasive index of liver fibrosis - In women

Abstract

Background: FIB-4 represents a noninvasive, composite index that is a validated measure of hepatic fibrosis, which is an important indicator of liver disease. To date, there are limited data regarding hepatic fibrosis in women. Methods: FIB-4 was evaluated in a cohort of 1227 women, and associations were evaluated in univariate and multivariate regression models among 4 groups of subjects classified by their human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection status. Results: The median FIB-4 scores were 0.60 in HIV-/HCV-women, 0.83 in HIV-/HCV+ women, 0.86 in HIV+/HCV-women, and 1.30 in HIV+/HCV+ women. In the HIV/HCV co-infected group, multivariate analysis showed that CD4+ cell count and albumin level were negatively associated with FIB-4 (P