Synthesis and characterization of transition metal complexes of Para-aminosalicylic acid with evaluation of their antioxidant activities

Abstract

Complexing behavior of Para-aminosalicylic acid (PAS) towards Mn(II), Fe(II), Co(II), Ni(II), Cu(ii), Zn(II), have been examined by Conductance and magnetic measurements and by UV-visible, IR and 1H NMR. Thermal decomposition properties of the complexes are investigated by thermogravimetric analysis (TGA). The free ligand and its complexes were tested for antioxidant activity and evaluation of IC50 values. It was found that PAS and its all complexes have low IC50 value than standard ascorbic acid. All complexes have lower IC50 value than PAS with Ni complex the least value. . Therefore, PAS and its complexes with these metal ions can act as antioxidants to reduce oxidative stresses.