Development and Analysis of Functionalized Poly(Lactide- Co-Glycolide)Polymer for Drug Delivery

Abstract

Functionalized polymer molecules are the backbone for formulation of targeted biomolecule delivery systems. We report here an effective method for the chemical synthesis of poly (lactide-co-glycolide)-1,4 diaminobutane (PLGA-DAB) in a controlled manner and an efficient gel permeation chromatography (GPC) method for analysis of functionalized PLGA. The synthetic method is simple, reproducible and the functionalized PLGA can be conjugated with any carboxylic acid-containing ligand and ultimately used for targeted drug delivery. The developed GPC analytical method is accurate, selective, precise and easily adaptable for analysing any other functionalized polymer with an amine group. These techniques provide an important basis for formulation scientists to develop functionalized polymers for targeted nanoparticle drug delivery.