P16 mutation spectrum in the premalignant condition Barrett's esophagus

29Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

Abstract

Background: Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a) have been detected in a wide variety of human cancers, but much less is known concerning the frequency and spectrum of p16 mutations in premalignant conditions. Methods and Findings: We have determined the p16 mutation spectrum for a cohort of 304 patients with Barrett's esophagus, a premalignant condition that predisposes to the development of esophageal adenocarcinoma. Forty seven mutations were detected by sequencing of p16 exon 2 in 44 BE patients (14.5%) with a mutation spectrum consistent with that caused by oxidative damage and chronic inflammation. The percentage of patients with p16 mutations increased with increasing histologic grade. In addition, samples from 3 out of 19 patients (15.8%) who underwent esophagectomy were found to have mutations. Conclusions: The results of this study suggest the environment of the esophagus in BE patients can both generate and select for clones with p16 mutations. © 2008 Paulson et al.

Cite

CITATION STYLE

APA

Paulson, T. G., Galipeau, P. C., Xu, L., Kissel, H. D., Li, X., Blount, P. L., … Reid, B. J. (2008). P16 mutation spectrum in the premalignant condition Barrett’s esophagus. PLoS ONE, 3(11). https://doi.org/10.1371/journal.pone.0003809

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free