Proteasome-independent p53 degradation

Abstract

The intracellular levels of the p53 tumor suppressor protein are regulated through various pathways and involve numerous regulatory components. A recent study published in Cell Research identifies a proteasome-independent pathway of p53 protein degradation in the nucleolus that is dependent on Def and Calpain3. © 2013 IBCB, SIBS, CAS. All rights reserved.